A mild hydration of nitriles catalysed by copper(ii) acetate.

نویسندگان

  • Patricia Marcé
  • James Lynch
  • A John Blacker
  • Jonathan M J Williams
چکیده

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

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عنوان ژورنال:
  • Chemical communications

دوره 52 7  شماره 

صفحات  -

تاریخ انتشار 2016